
What specific ways you can develop callus is by weight lifting without gloves. This can cause callus on your upper palms. Shoes, as another example, can affect the feet with callus. String instruments are known to cause callus on the players fingers. However, callus isn't necessarily bad. Thicker skin prevents blisters and help alleviate pain. For the string instrument player callus helps alleviate the pain from the tension of the strings and make playing easier. For dancers dancing barefoot can make performing turns less difficult.
A person that has callus can still develop blisters. Blisters in general are small pockets of fluid with the upper layers of the skin. They can either be filled with blood (AKA blood blisters) or with pus (infection). The most common blisters are filled with a clear fluid called serum that resembles water. Serum is the part of the blood that remain after red bloodcells and clotting agents have been removed.

A blood blister usually forms when a small blood vessel close to the surface of the skin breaks and blood leaks into a tear between the layers of skin. This can happen if the skin is crushed, pinched or squeezed really tightly.

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